HuagongsheHuagongshe Chemistry Print Report · For research reference only
Milbemycin A4 → HCID 101591928, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Milbemycin A4 | HCID 9959038 | — |
| Reactant | HCID 88399840 | HCID 88399840 | — |
| Product | HCID 101591928 | HCID 101591928 | 70% |
Reaction Steps
0.2 g of milbemycin A4 is added to a 2-day-old preculture of S. violascens produced according to H1 in 450 ml of medium 2, and the whole is shaken at 250 rpm. at 28° C. The course of the reaction is monitored by means of HPLC (high pressure liquid chromatography) (column 25 cm/0.5 cm, eluant hexane/dimethoxyethane 3:1, 1 ml/min., UV detector 220 nm). After shaking for 4 days and a 37% conversion rate, 70% 13β-hydroxymilbemycin A4 and 30% 14,15-epoxymilbemycin A4 are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05183749 |
| Source dataset | uspto-grants-1993_02 |
| ORD ID | ord-913d327ae87a493c8ddbe86c069f9da1 |
| Source note | uspto-grants-1993_02 |