HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Fluoroaniline → 4-[(2-Fluorophenyl)amino]-5,6-dihydro-2(1H)-pyridinone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Fluoroaniline | HCID 9584 | — |
| Reactant | 2,4-Piperidinedione | HCID 10887863 | — |
| Product | 4-[(2-Fluorophenyl)amino]-5,6-dihydro-2(1H)-pyridinone | HCID 15712494 | 82.2% |
Reaction Steps
A mixture of 2-fluoroaniline (0.98 g) and 2,4-dioxopiperidine (1.0 g) was heated at 120° for 2 h. The cooled mixture was triturated with dry ether (5×40 ml) and the solvent was decanted to leave the title compound (1.495 g), m.p. 98°-100°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05183820 |
| Source dataset | uspto-grants-1993_02 |
| ORD ID | ord-7ba40ddaf9564399b95a53c6c51609e1 |
| Source note | uspto-grants-1993_02 |