3-Fluoroaniline → HCID 19799244, compound

HRID 2081195Notes

Reaction equation

HRID 2081195 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:6]=[CH:7][CH:8]=1)[NH2:5].[O:9]=[C:10]1[CH2:15][C:14](=O)[CH2:13][CH2:12][NH:11]1>>[F:1][C:2]1[CH:3]=[C:4]([NH:5][C:14]2[CH2:13][CH2:12][NH:11][C:10](=[O:9])[CH:15]=2)[CH:6]=[CH:7][CH:8]=1

Participants

3

Reactant 2

HCID 97423-FluoroanilineHCID 108878632,4-Piperidinedione

Product 1

HCID 19799244HCID 19799244, compoundYield 67.1%

Procedure

A mixture of 3-fluoroaniline (2 g) and 2,4-dioxopiperidine (2.04 g) was heated at 120° under nitrogen for 1 h. The resultant solid was cooled and purified by FCC eluting with System A (100:8:1) to give the title compound (2.49 g), m.p. 188°-190°.

Workup

  1. temperaturewas heated at 120° under nitrogen for 1 h
  2. temperatureThe resultant solid was cooled
  3. custompurified by FCC
  4. washeluting with System A (100:8:1)

Sources & evidence

ORD record
ord-02b24708ec1e40b8a5abae44f7417325
Source dataset
uspto-grants-1993_02
Patent number
US05183820

Reaction notes

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