HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,5-Difluoroaniline → 4-[(2,5-Difluorophenyl)amino]-5,6-dihydro-2(1H)-pyridinone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,5-Difluoroaniline | HCID 67775 | — |
| Reactant | 2,4-Piperidinedione | HCID 10887863 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 4-[(2,5-Difluorophenyl)amino]-5,6-dihydro-2(1H)-pyridinone | HCID 15712497 | 20.5% |
Reaction Steps
A mixture of 2,5-difluoroaniline (6.45 g) and 2,4-dioxopiperidine (5.66 g) was heated under nitrogen for 6 h. The reaction mixture was then dissolved in ethanol (50 ml), adsorbed onto silica, and purified by FCC eluting with System A (150:8:1) to give the title compound (2.3 g), m.p. 252°-255°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05183820 |
| Source dataset | uspto-grants-1993_02 |
| ORD ID | ord-771d264da1a64f40ba416289324aebe6 |
| Source note | uspto-grants-1993_02 |