HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 3265055, compound → 8-Fluoro-1,2,3,9-tetrahydro-4H-carbazol-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 3265055 | HCID 3265055 | — |
| Catalyst | Cupric acetate | HCID 8895 | — |
| Catalyst | palladium(II) acetate | HCID 167845 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 8-Fluoro-1,2,3,9-tetrahydro-4H-carbazol-4-one | HCID 22147745 | 68.9% |
Reaction Steps
3-[(2-Fluorophenyl)amino]-2-cylcohexen-1-one (14.8 g), palladium (II) acetate (1 g), and copper (II) acetate (29.5 g) were heated together in DMF (10 ml) under nitrogen at 140° for 2 h. The solvent was removed in vacuo, and the residue was purified by FCC eluting with ether to give the title compound (10.1 g), m.p. 222°-224°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05183820 |
| Source dataset | uspto-grants-1993_02 |
| ORD ID | ord-2ba354f326464fce8bb2d64a6469a19f |
| Source note | uspto-grants-1993_02 |