2(1H)-Pyrimidinone, tetrahydro-1,3-dimethyl- → HCID 15712517, compound

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Reaction Steps

A mixture of 6-bromo-2,3,4,5-tetrahydro-5-methyl-1H-pyrido[4,3-b]indol-1-one (1.1 g) and cuprous cyanide (1.0 g) in 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidone (30 ml) was heated at 180° for 24 h. The mixture was poured onto ice (ca. 500 ml) and ferric (III) chloride (20 g), and stirred for 1 h. It was then extracted with dichloromethane (3×300 ml), and the combined organic extracts were washed with water (2×300 ml) and concentrated in vacuo. The residue was triturated with hexane (250 ml) followed by a mixture of ether/hexane (50:50; 100 ml) and finally with ether (60 ml) to give the title compound (620 mg), m.p. 230°-231°.

Provenance & Evidence