4-(Chloromethyl)-5-methyl-1-trityl-1H-imidazole → HCID 15712521, compound

HRID 2081212Notes

Reaction equation

HRID 2081212 reaction equation
[C:1]1([CH2:7][O:8][C:9]2[C:17]3[N:16]([CH2:18][O:19][CH2:20][C:21]4[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=4)[C:15]4[CH2:27][CH2:28][NH:29][C:30](=[O:31])[C:14]=4[C:13]=3[CH:12]=[CH:11][CH:10]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl[CH2:33][C:34]1[N:35]=[CH:36][N:37](C(C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[C:38]=1[CH3:39]>>[CH3:39][C:38]1[NH:37][CH:36]=[N:35][C:34]=1[CH2:33][N:29]1[CH2:28][CH2:27][C:15]2[N:16]([CH2:18][O:19][CH2:20][C:21]3[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=3)[C:17]3[C:9]([O:8][CH2:7][C:1]4[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=4)=[CH:10][CH:11]=[CH:12][C:13]=3[C:14]=2[C:30]1=[O:31]

Participants

3

Reactant 2

HCID 110469654-(Chloromethyl)-5-methyl-1-trityl-1H-imidazoleHCID 15712511HCID 15712511, compound

Product 1

HCID 15712521HCID 15712521, compoundYield 55.4%

Procedure

2,3,4,5-Tetrahydro-6-(phenylmethoxy)-5-[(phenylmethoxy)methyl]-1H-pyrido[4,3-b]indol-1-one (500 mg) was reacted with 4-(chloromethyl)-5-methyl-1-(triphenylmethyl)-1H-imidazole (671 mg) according to the method of Intermediate 35 to give the title compound (340 mg), m.p. 170°-172°. (The FCC Eluant was System A (100:8:1)).

Sources & evidence

ORD record
ord-8bcdbee7ab0e42e0adeae8a1a9da3acf
Source dataset
uspto-grants-1993_02
Patent number
US05183820

Reaction notes

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