Nitromethane → HCID 10331038, compound

Participants

Reaction Steps

To a solution of 7-fluoro-1-methyl-1H-indole-2-carboxaldehyde (1.80 g) in nitromethane (20 ml) was added ammonium acetate (780 mg) and the mixture was heated at reflux for 1 h. The solvent was removed in vacuo and the residue was suspended in ethyl acetate (300 ml). This suspension was washed with 8% aqueous sodium bicarbonate solution (2×300 ml), dried, and the solvent was removed in vacuo to leave the title compound (1.26 g) as a solid, m.p. 153°-155.5°.

Provenance & Evidence