Potassium Carbonate → HCID 19799241, compound

Participants

Reaction Steps

To a solution of N-[[1-[(dimethylamino)sulphonyl]-5-methyl-1H-imidazol -4-yl]methyl]-2,2,2-trifluoro-N-[2-(7-fluoro-1-methyl-1H-indol-2-yl)-ethyl]acetamide (230 mg) in methanol (10 ml) was added potassium carbonate (350 mg), and the mixture was heated at reflux for 2 h. The mixture was then diluted with ethyl acetate (100 ml), washed with 8% sodium bicarbonate solution (100 ml), dried, and evaporated in vacuo to leave an oil. This was purified by FCC eluting with System A (200:8:1) to give the title compound (110 mg) as a solid, m.p. 114°-115.5°.

Provenance & Evidence