HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 10427043, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | Methyl 5-chloro-1-(4-chlorophenyl)-4-oxo-1,4-dihydrocinnoline-3-carboxylate | HCID 10904198 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 10427043 | HCID 10427043 | — |
Reaction Steps
To 10 g (28.6 mmole) of the above methyl ester (from step 2) in 150 ml of p-dioxane there is added 10 ml (4 eq.) of concentrated HCl with stirring under a nitrogen atmosphere. The mixture is heated up and refluxed for 5 hours. After cooling, the mixture is poured into water with stirring. Free acid is collected by filtration and dried over vacuum at 50° C. (9.5 g, 99%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05183891 |
| Source dataset | uspto-grants-1993_02 |
| ORD ID | ord-32491294cd324ac19323f34c227eb09e |
| Source note | uspto-grants-1993_02 |