1,4-Dioxane hydrochloride → HCID 178425964, compound

HRID 2081257Notes

Reaction equation

HRID 2081257 reaction equation
C(OC([NH:8][C@H:9]([C:29]([NH:31][CH2:32][C:33]([O:35][C:36](=[O:50])[C@H:37]([CH:39]([CH2:43][C:44]1[CH:49]=[CH:48][CH:47]=[CH:46][CH:45]=1)[C:40]([O-:42])=[O:41])[NH2:38])=[O:34])=[O:30])[CH2:10][CH2:11][CH2:12][NH:13][C:14](=[NH:28])[NH:15][S:16]([C:19]1[C:24]([CH3:25])=[CH:23][C:22]([CH3:26])=[CH:21][C:20]=1[CH3:27])(=[O:18])=[O:17])=O)(C)(C)C.[ClH:51].O1CCOCC1>O1CCOCC1>[ClH:51].[C:24]1([CH3:25])[CH:23]=[C:22]([CH3:26])[CH:21]=[C:20]([CH3:27])[C:19]=1[S:16]([NH:15][C:14](=[NH:28])[NH:13][CH2:12][CH2:11][CH2:10][C@@H:9]([C:29]([NH:31][CH2:32][C:33]([O:35][C:36](=[O:50])[C@H:37]([CH:39]([CH2:43][C:44]1[CH:49]=[CH:48][CH:47]=[CH:46][CH:45]=1)[C:40]([OH:42])=[O:41])[NH2:38])=[O:34])=[O:30])[NH2:8])(=[O:18])=[O:17]

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 178425969HCID 178425969, compound

Product 1

HCID 178425964HCID 178425964, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

1.5 g (2.1 mmol) of compound (III) was dissolved in 30 ml of purified dioxane and 30 ml of 4N HCl/dioxane was added thereto. The mixture was stirred for 1 hour. After concentrating to dryness, the product was crystallized by adding dry ether. The crystals were centrifuged, washed with dry ether several times and dried. Thus 1.3 g of the titled compound was obtained.

Workup

  1. concentrationAfter concentrating to dryness
  2. customthe product was crystallized
  3. additionby adding dry ether
  4. washwashed with dry ether several times
  5. customdried

Sources & evidence

ORD record
ord-fd1d279a4097412497c076aff355a0f8
Source dataset
uspto-grants-1993_02
Patent number
US05183804

Reaction notes

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