Hydrochloric Acid → HCID 19799667, compound

Participants

Reaction Steps

Magnesium (1.44 g, 0.06 mol) suspended in diethyl ether (20 ml), was treated with a crystal of iodine, then a solution of bromoethane (6.54 g, 0.06 mol) in diethyl ether (15 ml) was added dropwise over 30 minutes. Reflux was maintained throughout this period by the heat of reaction. The mixture was stirred for 45 minutes before a solution of 5-(2-chloro-4-trifluoromethylphenoxy)-3-hydroxy-3-methylphthalide (5.38 g, 0.015 mol) dissolved in diethyl ether (20 ml) was added over 20 minutes. After stirring for a further 40 minutes, 50% hydrochloric acid (12 ml) was cautiously added, then the phases separated. The organic phase was washed with water 3×15 ml), the solvent stripped off and the residual oil distilled.

Provenance & Evidence