HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromophenol → 4-(2-Bromophenoxy)butyric acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromophenol | HCID 7244 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | Ethyl 4-bromobutyrate | HCID 76300 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 4-(2-Bromophenoxy)butyric acid ethyl ester | HCID 15070114 | 85.4% |
Reaction Steps
8.65 g of bromophenol and 8.75 g of 4-bromobutyric acid ethyl ester are dissolved in 120 ml of dimethylformamide, mixed with 32.6 g of cesium carbonate and stirred for 2 days at room temperature. The reaction mixture is filtered, the solvent is distilled off in a vacuum and the residue is distilled in a bulb tube at 180° C./0.4 mbar. 11 g of 4-(2-bromophenoxy)butyric acid ethyl ester is obtained as a colorless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05183925 |
| Source dataset | uspto-grants-1993_02 |
| ORD ID | ord-502ccf6aea974a858717eeda5255c69c |
| Source note | uspto-grants-1993_02 |