HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Iodophenol → 4-(2-Iodophenoxy)butyric acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Iodophenol | HCID 10784 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | Ethyl 4-bromobutyrate | HCID 76300 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 4-(2-Iodophenoxy)butyric acid ethyl ester | HCID 15070115 | 63.7% |
Reaction Steps
Under the conditions of example 2A, 25 g of 2-iodophenol and 22.16 g of 4-bromobutyric acid ethyl ester are reacted in 100 ml of dimethylformamide in the presence of 74 g of cesium carbonate, worked up, and 24.2 g of 4-(2-iodophenoxy)butyric acid ethyl ester with a boiling point of 200° C./0.02 mbar is obtained as a colorless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05183925 |
| Source dataset | uspto-grants-1993_02 |
| ORD ID | ord-c8691b83b9064d6da9d899fd6d95732d |
| Source note | uspto-grants-1993_02 |