反应详情

A solution of 1.4 g of 4-(2-bromophenoxy)-butyric acid in 22 ml of methanol is mixed with 1 g of Amberlyst 15 and stirred for 5 hours at room temperature. Then, it is filtered from the Amberlyst 15, the filtrate concentrated by evaporation, the residue is taken up in diethyl ether, washed with dilute sodium carbonate solution, dried (Na2SO4) and concentrated by evaporation. 1.5 g of 4-(2-bromophenoxy)-butyric acid methyl ester is obtained as a colorless oil.

1. filtrationThen, it is filtered from the Amberlyst 15
2. concentrationthe filtrate concentrated by evaporation
3. washwashed with dilute sodium carbonate solution
4. dry with materialdried (Na2SO4)
5. concentrationconcentrated by evaporation