Acetic Anhydride → HCID 15070135, compound

Participants

Reaction Steps

A solution of 60 mg of 4-[2-[(1E,3E)-(5RS)-5-hydroxy-1,3-tridecadienyl]-phenoxy]-butyric acid ethyl ester in 0.5 ml of pyridine is mixed with ice cooling and under argon atmosphere with 0.12 ml of acetic anhydride and stirred for 4 hours at room temperature. The reaction mixture is concentrated by evaporation and the residue is chromatographed on silica gel with n-hexane/ethyl acetate=95/5. 42 mg of 4-[2-[(1E,3E)-(5RS)-5-acetoxy-1,3-tridecadienyl]-phenoxy]-butyric acid ethyl ester is obtained as a colorless oil.

Provenance & Evidence