Sulfuric Acid → HCID 15070140, compound

Participants

Reaction Steps

A solution of 130 mg of 4-[2-[(1E,3E)-(5RS)-5-hydroxy-1,3-tridecadienyl]-phenoxy]butyric acid ethyl ester in 10 ml of methanol and 2.5 ml of 0.5 n sodium hydroxide solution is stirred under argon atmosphere for 3 hours at room temperature. The reaction mixture is poured on ice water, acidified to pH 5 with 0.5 n sulfuric acid and shaken out with ethyl acetate. The organic phase is dried, concentrated by evaporation and the residue is chromatographed on silica gel with n-hexane/diethyl ether=7/3. 78 mg of the title compound is obtained as a colorless oil.

Provenance & Evidence