HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl Ether → 4-[2-[(E)-2-iodovinyl]-phenoxy]-butan-1-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | 4-[2-[(E)-2-iodovinyl]-phenoxy]butyric acid ethyl ester | HCID 15070120 | — |
| Reactant | Aluminium lithium hydride | HCID 21226445 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 4-[2-[(E)-2-iodovinyl]-phenoxy]-butan-1-ol | HCID 15070142 | 54.3% |
Reaction Steps
A solution of 250 mg of 4-[2-[(E)-2-iodovinyl]-phenoxy]butyric acid ethyl ester in 5 ml of tetrahydrofuran is instilled into a suspension of 80 mg of lithium aluminum hydride at 0° C. with stirring and under argon atmosphere. Then, it is stirred for an hour with ice cooling, the mixture is decomposed under argon atmosphere with ice water, shaken out with diethyl ether, dried (Na2SO4) and concentrated by evaporation. 120 mg of 4-[2-[(E)-2-iodovinyl]-phenoxy]-butan-1-ol is obtained as a yellow oil, which is further reacted as a crude product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05183925 |
| Source dataset | uspto-grants-1993_02 |
| ORD ID | ord-042a509286504dbda294c99e3f1377be |
| Source note | uspto-grants-1993_02 |