Iodine → HCID 15070148, compound

Participants

Reaction Steps

Under the conditions of example 2D, 696 mg of 5-(2-iodophenoxy)-valeric acid ethyl ester and 3.2 g of (E)-1,2-bis-(tri-n-butylstannyl)-ethylene (50%) are reacted in the presence of 47 mg of tetrakis-(triphenylphosphine)palladium, treated with 1.02 g of iodine, worked up and chromatographed on silica gel with n-hexane/ethyl acetate-95/5. 430 mg of 5-[2-[(E)-2-iodovinyl]-phenoxy]-valeric acid ethyl ester is obtained as an oily crude product, which is used without further purification in the next stage.

Provenance & Evidence