反应详情

3-Trifluoromethylphenol (compound I) (5.0 g) was dissolved in carbon disulfide (3.0 ml) and then to the solution was added a solution of bromine (5.0 g) in carbon disulfide (2.0 ml) over a period of about 15 minutes at 25° C. or less, followed by allowing the reaction to proceed for 2 hours at 25° C. The resulting reaction mixture was added to water (10 ml) and then subjected to repeated extraction with methylene chloride. The methylene chloride layer was washed with aqueous sodium hydrogen-carbonate solution and then with water and dehydration-dried by adding anhydrous sodium sulfate. The solvent was removed by distillation under reduced pressure to obtain 3-trifluoromethyl-4-bromophenol (compound II, 4.4 g).

1. customthe reaction
2. customThe resulting reaction mixture
3. extractionextraction with methylene chloride
4. washThe methylene chloride layer was washed with aqueous sodium hydrogen-carbonate solution
5. dry with materialwith water and dehydration-dried
6. additionby adding anhydrous sodium sulfate
7. customThe solvent was removed by distillation under reduced pressure