Methyl Isocyanate → Fluzinamide

HRID 2081415Notes

Reaction equation

[F:1][C:2]([F:15])([F:14])[C:3]1[CH:4]=[C:5]([CH:11]=[CH:12][CH:13]=1)[O:6][CH:7]1[CH2:10][NH:9][CH2:8]1.[CH3:16][N:17]=[C:18]=[O:19]>>[CH3:16][NH:17][C:18]([N:9]1[CH2:10][CH:7]([O:6][C:5]2[CH:11]=[CH:12][CH:13]=[C:3]([C:2]([F:1])([F:14])[F:15])[CH:4]=2)[CH2:8]1)=[O:19]

Participants

Reactant 2

HCID 12228Methyl Isocyanate

HCID 111385383-[3-(Trifluoromethyl)phenoxy]azetidine

Product 1

HCID 53467Fluzinamide

Procedure

The compound was prepared from 3-[3-(trifluoromethyl)phenoxy)azetidine and methylisocyanate as described in Example 4 of U.S. Pat. No. 4,226,861, m.p. 145°-147° C.

Sources & evidence

ORD record: ord-837629517fac43578fa9f84dd183fb56
Source dataset: uspto-grants-1993_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05183902

Reaction notes

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