HuagongsheHuagongshe Chemistry Print Report · For research reference only
Butyl ether → HCID 59347922, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Butyl ether | HCID 8909 | — |
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | {1-[Amino(phenyl)methyl]cyclopentyl}dimethylamine | HCID 11521393 | — |
| Reactant | HCID 59347806 | HCID 59347806 | — |
| Reactant | HCID 178506676 | HCID 178506676 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 59347922 | HCID 59347922 | 42% |
Reaction Steps
The title compound (1.22 g; 42%) was prepared from 1-{methyl[2-(methyloxy)ethyl]amino}cyclopentanecarbonitrile D35 (2.0 g; 11 mmol), and phenyllithium in di-n-butylether (6.7 ml of 1.8M solution; 12 mmol) in THF (25 ml), followed by reaction with sodium borohydride (1.25 g; 33 mmol) in methanol (25 ml) in a similar manner to that described in D2. Mass Spectrum (Electrospray LC/MS). Found 263 (MH+). C16H26N2O requires 262. Ret. time 1.57 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07745642B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-b5fd27da5fe24169a153b77af21597fb |
| Source note | uspto-grants-2010_06 |