Sulfuric Acid → HCID 178497878, compound

Participants

Reaction Steps

A solution of 88.5 g of 4-(trans-4-formylcyclohexyl)benzoic acid methyl ester in 700 ml of toluene was treated while stirring with 1.5 ml of 10% (v/v) sulfuric acid and heated to boiling for 1 hour, with damp toluene being distilled off and being replaced by the addition of fresh toluene. Subsequently, the reaction solution was treated with 1 ml of triethylamine. The mixture was washed three times with 150 ml of water each time, dried over sodium sulfate, filtered and concentrated. Twofold recrystallization of the residue from tert. butyl methyl ether at -25° C. gave 75.4 g of pure 4-[trans-4-(1,3-dioxolan-2-yl) cyclohexyl]benzoic acid methyl ester with m.p. 110°-111° C.

Provenance & Evidence