反应详情

A mixture of 2-[2(R/S)-hydroxy-2-(2-methoxy-5-ethyl-6-methylpyridin-3-yl)ethyl]benzoxazole (72 mg, 0.23 mmol) and pyridine hydrochloride (133 mg, 1.2 mmol), under a nitrogen atmosphere, was placed in a preheated oil bath (165° C.) for 5 minutes. The reaction flask was removed, cooled, and water added to give a solid. This crude product was extracted into chloroform, dried (MgSO4) and the solvent evaporated to yield pure product. Recrystallization from methanol gave analytically pure product, mp 262°-264° C.

1. customunder a nitrogen atmosphere, was placed in a preheated oil bath
2. customThe reaction flask was removed
3. temperaturecooled
4. additionwater added
5. customto give a solid
6. extractionThis crude product was extracted into chloroform
7. dry with materialdried (MgSO4)
8. customthe solvent evaporated
9. customto yield pure product
10. customRecrystallization from methanol
11. customgave analytically pure product, mp 262°-264° C.