2-Benzyloxy-3-pyridinecarbaldehyde → 3-[2-(Benzoxazol-2-yl)ethenyl]-5-(1-hydroxyethyl)-6-methyl-2-benzyloxypyridine

HRID 2081541Notes

Reaction equation

HRID 2081541 reaction equation
[CH2:1]([O:8][C:9]1[C:14]([CH:15]=O)=[CH:13][C:12]([CH:17]([OH:19])[CH3:18])=[C:11]([CH3:20])[N:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(OC1N=CC=CC=1C=O)[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1>>[O:8]1[C:27]2[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=2[N:10]=[C:9]1[CH:14]=[CH:15][C:14]1[C:9]([O:8][CH2:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)=[N:10][C:11]([CH3:20])=[C:12]([CH:17]([OH:19])[CH3:18])[CH:13]=1

Participants

3

Reactant 2

HCID 189739592-Benzyloxy-3-pyridinecarbaldehydeHCID 197800412-Benzyloxy-5-(1-hydroxyethyl)-6-methylpyridin-3-carboxaldehyde

Product 1

HCID 678838823-[2-(Benzoxazol-2-yl)ethenyl]-5-(1-hydroxyethyl)-6-methyl-2-benzyloxypyridine

Procedure

Following substantially the same procedure described in Example 3, Step E, but substituting 2-benzyloxy-5-(1-hydroxyethyl)-6-methylpyridin-3-carboxaldehyde for the benzyloxynicotinaldehyde compound used therein, the title compound is obtained.

Sources & evidence

ORD record
ord-afa0d3cc7423476ca6c809c0c9d7b74e
Source dataset
uspto-grants-1993_02
Patent number
US05185251

Reaction notes

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