HuagongsheHuagongshe Chemistry Print Report · For research reference only
O-methyl hydrazinecarbothioate → 5-[2-(4-acetamidophenyl)ethenyl]-6H-1,3,4-thiadiazin-2(3H)one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | O-methyl hydrazinecarbothioate | HCID 10171237 | — |
| Reactant | 1-Chloro-4-(4-acetamidophenyl)-2-oxo-3-butene | HCID 54055357 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 5-[2-(4-acetamidophenyl)ethenyl]-6H-1,3,4-thiadiazin-2(3H)one | HCID 54187906 | — |
Reaction Steps
A mixture containing 4.0 g of 1-chloro-4-(4-acetamidophenyl)-2-oxo-3-butene (J. Org. Chem., 28, 2446, 1963) and 2.3 g of hydrazinecarbothioic acid O-methylester in 150 ml of toluene was refluxed for 3 h. The crystals were filtered and washed with toluene. Yield 3.0 g (65%), mp. 235°-240° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05185332 |
| Source dataset | uspto-grants-1993_02 |
| ORD ID | ord-358e97d831d64e458479d26356bd37bc |
| Source note | uspto-grants-1993_02 |