HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 19780233, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Urea | HCID 1176 | — |
| Reactant | 2-(4-Fluorobenzoyl)cyclohexan-1-one | HCID 19780230 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 19780233 | HCID 19780233 | 61.8% |
Reaction Steps
A mixture of 2-(4-fluorobenzoyl)cyclohexanone (14 g), urea (7.6 g), conc. hydrochloric acid (8 ml) and ethanol (40 ml) is refluxed for 8 hours. After cooling, the reaction mixture is diluted with water and washed with methylene chloride. The aqueous layer is made alkaline with potassium carbonate, and the precipitated crystal is separated by filtration and recrystallized from N,N-dimethylformamide-ethanol to give the desired compound (9.6 g), m.p. 248°-253° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05185338 |
| Source dataset | uspto-grants-1993_02 |
| ORD ID | ord-e167a9f12d6f44b898acc6a36b36e842 |
| Source note | uspto-grants-1993_02 |