Pentanoic acid, 2-acetyl-, ethyl ester → HCID 178439771, compound

Participants

Reaction Steps

A mixture of ethyl 2-n-propylacetoacetate (0.5 mole), trifluoroacetamidine (0.67 mole) and sodium ethoxide (1 mole) in ethanol was heated at reflux temperature overnight and then evaporated to dryness. The residue was triturated in water and acidified with glacial acetic acid to yield the title compound. TLC, Silica gel (cyclohexane-ethyl acetate, 1:1) Rf 0.80 1H NMR (CDCl3): δ 0.95 (t,3H) 1.25 (t,3H) 1.57 (m,2H) 2.58 (q,2H) 2.70 (q,2H).

Provenance & Evidence