Sodium Methoxide → HCID 53884800, compound

Participants

Reaction Conditions

Reaction Steps

2-p-Chlorobenzyl-6-cyanopyridine (1.69 g, 0.0074 moles) was added to a solution of sodium methoxide [prepared by dissolving sodium metal (0.19 g, 0.0081 gram atoms) in methanol (20 ml)] under nitrogen, and the mixture stirred at 20° C. for 17 hours. The methanol was evaporated, the residue taken up in chloroform, neutralised with acetic acid and the precipitate filtered off on HYFLO. Concentration of the filtrate gave methyl 6-p-chlorobenzyl-2-picoline imidate (1.20 g, 62%) which was used in the next stage without further purification.

Provenance & Evidence