Ammonium Chloride → HCID 19780234, compound

HRID 2081584Notes

Reaction equation

HRID 2081584 reaction equation
[Cl:1][C:2]1[CH:18]=[CH:17][C:5]([CH2:6][C:7]2[N:12]=[C:11]([C:13](=[NH:16])OC)[CH:10]=[CH:9][CH:8]=2)=[CH:4][CH:3]=1.[Cl-].[NH4+:20]>C(O)C>[ClH:1].[Cl:1][C:2]1[CH:18]=[CH:17][C:5]([CH2:6][C:7]2[N:12]=[C:11]([C:13]([NH2:20])=[NH:16])[CH:10]=[CH:9][CH:8]=2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 25517Ammonium ChlorideHCID 53884800HCID 53884800, compound

Product 1

HCID 19780234HCID 19780234, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of methyl 6-p-chlorobenzyl-2-picoline imidate (1.2 g, 0.00046 moles) and ammonium chloride (0.27 g, 0.0051 moles) in ethanol (10 ml) was refluxed for 6 hours. Removal of the ethanol in vacuo gave 6-p-chlorobenzyl-2-picoline amidine hydrochloride which was used in the final stage without further purification.

Workup

  1. temperaturewas refluxed for 6 hours
  2. customRemoval of the ethanol in vacuo

Sources & evidence

ORD record
ord-9c540901a59e43e0bcaf487c572fe9bb
Source dataset
uspto-grants-1993_02
Patent number
US05185339

Reaction notes

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