Sodium Methoxide → HCID 53896835, compound

Participants

Reaction Conditions

Reaction Steps

2-(o-Chlorobenzyl)-6-cyanopyridine (5.0 g, 0.022 moles) was added to a solution of sodium methoxide in methanol [prepared by dissolving sodium metal (0.55 g, 0.024 g atoms) in methanol (50 ml)] and the mixture stirred at 20° C. for 5 hours. The methanol was evaporated, the residue taken up in dichloromethane and the precipitate filtered off through a silica bed. Removal of the solvent from the filtrate gave methyl 6-(o-chlorobenzyl)-2-picoline imidate (5.5 g, 100%) as a brown oil which was used in the next stage without further purification.

Provenance & Evidence