反应详情

A mixture of 3.2 parts of intermediate 2, namely α-phenyl-7-quinolinemethanol, 8 parts of thionyl chloride and 65 parts of dichloromethane was stirred for 4 hours at room temperature. The reaction mixture was evaporated and the residue was poured into water. The product was extracted with dichloromethane (3×39 parts) and the combined extracts were dried, filtered and evaporated, yielding 3.4 parts (98.5%) of 7-(chlorophenylmethyl)quinoline (interm. 23). In a similar manner there were also prepared the intermediates listed in Table 2.

1. customThe reaction mixture was evaporated
2. additionthe residue was poured into water
3. extractionThe product was extracted with dichloromethane (3×39 parts)
4. customthe combined extracts were dried
5. filtrationfiltered
6. customevaporated