HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2081610Generated: October 27, 2026
Imidazole → 6-(1H-imidazol-1-ylmethyl)quinoline dihydrochloride
https://huagongshe.com/reaction/2081610
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Imidazole | HCID 795 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 6-(Chloromethyl)quinoline | HCID 14666198 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 6-(1H-imidazol-1-ylmethyl)quinoline dihydrochloride | HCID 19967105 | 48% |
Reaction Steps
A mixture of 12.3 parts of 6-(chloromethyl)quinoline, 9.5 parts of 1H-imidazole, 19.2 parts of potassium carbonate and 135 parts of N,N-dimethylformamide was stirred for 3 hours at 80° C. After evaporation to dry, the residue was taken up in water and further purified according to similar procedures as described in example 12, yielding 10 parts (48%) of 6-(1H-imidazol-1-ylmethyl)quinoline dihydrochloride; mp. 254.6° C. (compound 19).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05185346 |
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| Source dataset | uspto-grants-1993_02 |
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| ORD ID | ord-08373da993484e0094fc2413aa6efcf8 |
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| Source note | uspto-grants-1993_02 |
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