Acetyl chloride → HCID 19780329, compound

Participants

Reaction Conditions

Reaction Steps

Acetyl chloride (1.04 mL, 14.7 mmol) was added in one portion to a slurry of 3-amino-5-undecyl-1H-1,2,4-triazole (3.50 g, 14.7 mmol) in THF (100 mL). The resulting slurry was stirred (1 hour, 25° C.), then concentrated in vacuo. The residue was suspended in ethyl acetate (300 mL), washed with ice cold water (2×100 mL), washed with ice cold brine (1×100 mL), then dried (MgSO4) and concentrated to yield 3.66 g (89.3%) of 2-acetyl-3-amino-5-undecyl-2H-1,2,4-triazole as a waxy solid.

Provenance & Evidence