1-Bromoundecane → HCID 10537926, compound

Participants

Reaction Conditions

Reaction Steps

A methanol solution of sodium methoxide was generated by dissolving sodium (2.06 g, 89.6 mmol) in methanol (300 mL). 3-Amino-1,2,4-triazole (7.5 g, 89.6 mmol) was added and the resulting solution was stirred (10 minutes, 25° C.). Undecylbromide (20.0 mL, 89.6 mmol) was then added and the resulting solution was heated under reflux for 24 hours. The resulting solution was cooled (25° C.) and concentrated in vacuo. The residue was taken up in ethyl acetate (450 mL), washed with brine (2×150 mL), then dried (MgSO4) and concentrated in vacuo. The resulting solid was dissolved in a minimal amount of chloroform and chromatographed on silica (98:2 chloroform:methanol) to yield 3.0 g (14.0%) of 3-amino-2-undecyl-1,2,4 -triazol (analysis for C13H26N4 : Calcd: C, 65.50; H, 10.99; N, 23.50; Found: C, 65.49; H, 10.98; N, 23.88), 4.0 g (18.7%) of 3-amino-1-undecyl-1,2,4-triazole (analysis for C13H26N4 : Calcd: C, 65.50; H, 10.99; N, 23.50; Found: C, 65.42; H, 10.93; N, 23.48), and 0.9 g (4.2%) of 3-amino-4-undecyl-1,2,4-triazole (analysis for C13H26N4 : Calcd: C, 65.50; H, 10.99; N, 23.50; Found: C, 65.20; H, 10.92; N, 23.52).

Provenance & Evidence