HCID 10626346, compound → HCID 178443213, compound

HRID 2081656Notes

Reaction equation

HRID 2081656 reaction equation
C([N:4]1[C:8]([S:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22])=[N:7][N:6]=[C:5]1[NH:23][C:24]([NH:26][C:27]1[C:32]([CH:33]([CH3:35])[CH3:34])=[CH:31][CH:30]=[CH:29][C:28]=1[CH:36]([CH3:38])[CH3:37])=[O:25])(=O)C>CO>[CH3:38][CH:36]([C:28]1[CH:29]=[CH:30][CH:31]=[C:32]([CH:33]([CH3:34])[CH3:35])[C:27]=1[NH:26][C:24]([NH:23][C:5]1[NH:4][C:8]([S:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22])=[N:7][N:6]=1)=[O:25])[CH3:37]

Participants

3

Reactant 1

HCID 10626346HCID 10626346, compound

Product 1

HCID 178443213HCID 178443213, compoundYield 63.2%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The urea of Example 14 (4.4 g, 0.0081 mol) was stirred in methanol (100 mL) at room temperature for 2 hours, the solution was then allowed to stand overnight. The solid obtained was filtered and dried in vacuo to give a white solid (2.57 g), m.p. 131°-135° C.

Workup

  1. customThe solid obtained
  2. filtrationwas filtered
  3. customdried in vacuo

Sources & evidence

ORD record
ord-89176b68bf73424196c0a1f9dc0a37c4
Source dataset
uspto-grants-1993_02
Patent number
US05185358

Reaction notes

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