Potassium sodium tartarate → HCID 22408489, compound

Participants

Reaction Conditions

Reaction Steps

5,10-Dihydro-2-(N-Acetyl-N-ethylamino)indeno[1,2-b]indole (0.5 g, 1.7 mM) in dry tetrahydrofuran (80 cm3), protected under an atmosphere of nitrogen, was treated with lithium aluminum hydride (0.3 g) during 1 hour. The reaction mixture was then heated to 50° C. for a further 1 hour, cooled, and saturated sodium potassium tartrate (5 cm3) added. The solvent layer was decanted from the aqueous residue, and the latter washed with tetrahydrofuran (3×8 cm3). The combined organic phase and washing were filtered through phase transfer paper and evaporated to yield a yellow solid. This was crystallised from 95% ethanol to afford the title compound 0.35 g as pale yellow prisms, M.p. 204°-206° C. After column chromatography (silica: ethyl acetate/60°-80° petrol), the M.p. of the compound was raised to 205°-206° C. (0.26 g, 55%).

Provenance & Evidence