2-Chlorobenzenesulfonamide → HCID 19780393, compound

HRID 2081704Notes

Reaction equation

[CH2:1]([O:5][C:6]([NH:8][C:9]1[CH:10]=[C:11]([CH:25]=[CH:26][CH:27]=1)[CH2:12][N:13]1[C:21]2[C:16](=[CH:17][C:18]([C:22](O)=[O:23])=[CH:19][CH:20]=2)[CH:15]=[CH:14]1)=[O:7])[CH:2]([CH3:4])[CH3:3].[Cl:28][C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=1[S:35]([NH2:38])(=[O:37])=[O:36]>>[CH2:1]([O:5][C:6]([NH:8][C:9]1[CH:10]=[C:11]([CH:25]=[CH:26][CH:27]=1)[CH2:12][N:13]1[C:21]2[C:16](=[CH:17][C:18]([C:22]([NH:38][S:35]([C:30]3[CH:31]=[CH:32][CH:33]=[CH:34][C:29]=3[Cl:28])(=[O:37])=[O:36])=[O:23])=[CH:19][CH:20]=2)[CH:15]=[CH:14]1)=[O:7])[CH:2]([CH3:3])[CH3:4]

Participants

Reactant 2

HCID 814102-Chlorobenzenesulfonamide

HCID 19780405HCID 19780405, compound

Product 1

HCID 19780393HCID 19780393, compound

Procedure

Using a similar procedure to that described in Example 29, the carboxylic acid (Example 28) was reacted with 2-chlorobenzene sulphonamide to give N-{1-[3-(isobutoxycarbonylamino)benzyl]indol-5-ylcarbonyl}-2-chlorobenzene sulphonamide.

Sources & evidence

ORD record: ord-129172b1ca3a42a58cc10d936012e834
Source dataset: uspto-grants-1993_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05185361

Reaction notes

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