Methanol → 2-(4-Fluorophenyl)-4-(3-trifluoromethylphenyl)-5-methoxypyrimidine

HRID 208173Notes

Reaction equation

HRID 208173 reaction equation
[CH3:28][O-:29].[CH3:31][OH:32].[CH3:33][O:34][CH2:35][CH2:36][O:37][CH3:38].[F:1][c:2]1[cH:3][cH:4][c:5](-[c:8]2[n:9][cH:10][c:11]([S:24]([CH3:25])(=[O:26])=[O:27])[c:12](-[c:14]3[cH:15][c:16]([C:20]([F:21])([F:22])[F:23])[cH:17][cH:18][cH:19]3)[n:13]2)[cH:6][cH:7]1.[Na+:30]>>[F:1][c:2]1[cH:3][cH:4][c:5](-[c:8]2[n:9][cH:10][c:11]([O:29][CH3:28])[c:12](-[c:14]3[cH:15][c:16]([C:20]([F:21])([F:22])[F:23])[cH:17][cH:18][cH:19]3)[n:13]2)[cH:6][cH:7]1

Participants

6

Reactant 5

HCID 887MethanolHCID 923Sodium ionHCID 80711,2-DimethoxyethaneHCID 3826051MethoxideHCID 148836702-(4-Fluorophenyl)-4-(3-trifluoromethylphenyl)-5-methanesulfonylpyrimidine

Product 1

HCID 117253022-(4-Fluorophenyl)-4-(3-trifluoromethylphenyl)-5-methoxypyrimidine

Sources & evidence

ORD record
ord-01035be7b7ce4c4798799b5801a45aa8
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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