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HRID2081743

反应详情

EQUATION

反应方程式

HRID 2081743 的结构方程式

REACTANTS

反应物

2
结构：CC(C)(C)c1cc(C=O)cc(C(C)(C)C)c1O
HCID73219

3,5-Di-tert-butyl-4-hydroxybenzaldehyde

C15H22O2

结构：N[C@@H]1C(=O)N2C[C@@](C(=O)OCc3ccc([N+](=O)[O-])cc3)(N3CCN(N=Cc4ccccc4)C3=O)S[C@H]12
HCID54330068

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)(C)c1cc(C=N[C@@H]2C(=O)N3C[C@@](C(=O)OCc4ccc([N+](=O)[O-])cc4)(N4CCN(N=Cc5ccccc5)C4=O)S[C@H]23)cc(C(C)(C)C)c1O
HCID135979311

未命名化合物

收率 98.6%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：c1ccccc1
溶剂HCID241

Benzene

C6H6

PROCEDURE

实验过程

30 ml of benzene was added to 1.00 g of (3R,5R,6R)-6-amino-3-(3-benzylideneamino-2-oxo-imidazolidin-1-yl)-3-(p-nitrobenzyloxycarbonyl)-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane and 0.46 g of 3,5-di-tert-butyl-4-hydroxybenzaldehyde. The mixture was subjected to azeotropy and dehydration under reflux for 1 hour using a Dean-Stark aparatus. The reaction mixture was cooled, and the solvent was removed by distillation under reduced pressure to obtain 1.40 g (yield: 98.6%) of (3R,5R,6R)-3-(3-benzylideneamino-2-oxoimidazolidin-1-yl)-6-(3,5-di-tert-butyl-4-hydroxybenzylideneamino)-3-(p-nitrobenzyloxycarbonyl)-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane.

WORKUP

后处理

  1. temperatureunder reflux for 1 hour
  2. temperatureThe reaction mixture was cooled
  3. customthe solvent was removed by distillation under reduced pressure