HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cornforth reagent → 1-(5-Methyl-2-thienyl)-2-propanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cornforth reagent | HCID 2724130 | — |
| Reactant | α-Ethyl-5-methyl-2-thiophenemethanol | HCID 19780497 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-(5-Methyl-2-thienyl)-2-propanone | HCID 15852904 | — |
Reaction Steps
A solution of 1-(5-methylthien-2-yl)propanol from above (20 mmol) and pyridinium dichromate (9.03 g, 24 mmol) in 100 mL CH2Cl2 was stirred for 18 h. The reaction was then filtered through Celite and the filtrate was concentrated. The resulting residue was purified by chromatography (silica gel, etherhexanes, 1:9) to afford 1.86 g (60% over the two steps) of the desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05185363 |
| Source dataset | uspto-grants-1993_02 |
| ORD ID | ord-c3bd5dd98b674a9b85532ccd407a99bc |
| Source note | uspto-grants-1993_02 |