Benzene → 2-(3-Thienyl)-1,3-dioxolane

Participants

Reaction Steps

In a 100 mL roundbottom flask equipped with a dean stark trap and a reflux condenser, thiophene-3-carboxaldehyde and p-toluenesulfonic acid were dissolved in benzene (50 mL). The mixture was heated to reflux overnight. The reaction was cooled, washed with sat'd sodium bicarbonate, water, dried (MgSO4) and concentrated. Purification by fractional distillation (93°-95° C., 7.5 mm Hg) afforded 45.3 g (72%) of the desired dioxolane as a clear liquid.

Provenance & Evidence