反应详情

温度

23 °C

To a 4.5% solution of 90% aqueous formic acid in methanol was added 120 mg of 10% palladium on carbon catalyst under nitrogen. To this suspension was added 150 mg of 6-phenyl-4-benzyloxycarbonylamino-4H-[1,2,4]triazolo-[4,3-a][1,4]benzodiazepin. The reaction mixture was stirred under nitrogen at 23° C. for 1.5 hours and filtered through Celite. The filtrate was concentrated under reduced pressure and azeotropically dried with toluene to yield the title compound.

1. filtrationfiltered through Celite
2. concentrationThe filtrate was concentrated under reduced pressure
3. dry with materialazeotropically dried with toluene