Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Methoxybenzyl alcohol → p-Methoxybenzyl acrylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Methoxybenzyl alcohol | HCID 7738 | — |
| 반응물 | (E)-3-[2-n-Butyl-1-[(2-chlorophenyl)methyl]-4-hydroxymethyl-1H-imidazol-5-yl]-2-(2-thienyl)methyl-2-propenoic acid | HCID 70041240 | — |
| 생성물 | p-Methoxybenzyl acrylate | HCID 346146 | — |
반응 단계
(E)-3-[2-n-Butyl-1-[(2-chlorophenyl)methyl]-4-hydroxymethyl-1H-imidazol-5-yl]-2-(2-thienyl)methyl-2-propenoic acid, prepared as in Example 19, is esterified with 4-methoxy-benzyl alcohol to give the p-methoxybenzyl propenoate. The 4-hydroxymethyl group in acetone is oxidized using an acidic aqueous solution containing chromic acid (Jones' reagent) and the ester is hydrolyzed using 10% sodium hydroxide to give the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05185351 |
| 출처 데이터셋 | uspto-grants-1993_02 |
| ORD ID | ord-ef255aa7d83943e58570b79335d52856 |
| 출처 메모 | uspto-grants-1993_02 |