HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 3-benzyl-3-(2-thienyl)propanoate → (E)-3-[2-n-Butyl-1-{(2-chlorophenyl)methyl}-1H-imidazol-5-yl]-2-{1-(2-thienyl)pentyl}-2-propenoic Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 3-benzyl-3-(2-thienyl)propanoate | HCID 10038247 | — |
| Reactant | 1-(2-chlorophenyl)methyl-5-carboxymethyl-2-propylthio-1H-imidazole | HCID 19351554 | — |
| Reactant | (E)-3-[2-n-butyl-1-{(2-chlorophenyl)methyl}-1H-imidazol-5-yl]-2-(4-pyridyl)-methyl-2-propenoic acid | HCID 86746549 | — |
| Product | (E)-3-[2-n-Butyl-1-{(2-chlorophenyl)methyl}-1H-imidazol-5-yl]-2-{1-(2-thienyl)pentyl}-2-propenoic Acid | HCID 10027726 | — |
Reaction Steps
The title compound was prepared using the procedure of Example 1 (i, ii, iii, iv [Method B]) replacing methyl 3(2-thienyl)propanoate with methyl 3-benzyl-3-(2-thienyl)propanoate [prepared following the procedure described in Tetra. 44 (7) 2055 (1988)]; mp 200°-202° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05185351 |
| Source dataset | uspto-grants-1993_02 |
| ORD ID | ord-6f3dc5db5a784aadaef2da660ebdf0f1 |
| Source note | uspto-grants-1993_02 |