HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 4-(hydroxymethyl)benzoate → (E)-3-[2-n-Propyl-1-{(4-carboxyphenyl)methyl}-1h-imidazol-5-yl]-2-(2-thienyl)methyl-2-propenoic Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 4-(hydroxymethyl)benzoate | HCID 81325 | — |
| Reactant | 3-[2-Butyl-3-(2-chloro-benzyl)-3H-imidazol-4-yl]-2-thiophen-2-ylmethyl-acrylic acid | HCID 10047444 | — |
| Reactant | Methyl ether hydrochloride | HCID 21585225 | — |
| Product | (E)-3-[2-n-Propyl-1-{(4-carboxyphenyl)methyl}-1h-imidazol-5-yl]-2-(2-thienyl)methyl-2-propenoic Acid | HCID 36688250 | — |
Reaction Steps
The title compound was prepared using the procedure of Example 1 replacing valermamidine methyl ether hydrochloride with butyramidine methyl ether hydrochloride and replacing 2-chlorbenzyl alcohol with 4-carbomethoxybenzyl alcohol; mp 250° C. (d).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05185351 |
| Source dataset | uspto-grants-1993_02 |
| ORD ID | ord-526263fc19714ede8690bdea769aa4ab |
| Source note | uspto-grants-1993_02 |