Potassium Hydroxide → HCID 53792932, compound

Participants

Reaction Steps

A slurry containing 14.46 g (26.14 mmol) of methyl(E)-3-[2-n-butyl-1-{(4-carbomethoxynaphth-1-yl)methyl}-1H-imidazol-5-yl]-2-(2-thienyl)methyl-2-propenoate, 8.38 g (2.09 mmol) of potassium hydroxide in a mixture of 165 mL of ethanol and 85 mL of water was stirred at ambient temperature for 18 hours. Concentration under vacuum and dilution with water gave 400 mL of a clear solution. Adjustment of the pH to 4.03 with hydrochloric acid gave crystals which when recrystallized from methanol gave 9.89 g (80%) of colorless crystals; mp 218°-219° C. as a partial hydrate.

Provenance & Evidence