HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2081880Generated: October 31, 2026
Hydrochloric Acid → Benzoic acid, 2-hydroxy-4-methyl-, methyl ester
https://huagongshe.com/reaction/2081880
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Methanol | HCID 887 | — |
| Reactant | 2-Hydroxy-p-toluic acid | HCID 5788 | — |
| Product | Benzoic acid, 2-hydroxy-4-methyl-, methyl ester | HCID 78400 | 94% |
Reaction Steps
To a suspension of 10 g (0.0651 mol) of 4-methylsalicylic acid in 150 mL of methanol was added 50 mL of ethereal hydrochloric acid. The reaction mixture was heated at 60° C. for 60 hours. The solvent was removed under vacuum. After adding hexane-ethyl acetate, the resulting solid was filtered and the filtrate was evaporated to give 10.2 g (94%) of product as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05185351 |
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| Source dataset | uspto-grants-1993_02 |
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| ORD ID | ord-aa5bfdc169184cba853d40784ce66fcf |
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| Source note | uspto-grants-1993_02 |
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