1,3-Dioxolane, 2-[(4-nitrophenyl)methyl]- → HCID 14858790, compound

Participants

Reaction Steps

Compound III (231 mg), from Example 6, was dissolved in methanol (about 3 ml) and the mixture flushed with nitrogen. Pd/C (120 mg) was added to the mixture and the sides of the reaction flask were rinsed with methanol (about 2 ml). The mixture was flushed with nitrogen and then flushed with hydrogen. The reaction mixture was stirred for 45 minutes, and then filtered through Celite. The Celite was rinsed several times with methanol and the filtrate and rinses were rotoevaporated to yield 184.4 mg (90.6 percent yield) of Compound IV.

Provenance & Evidence