HCID 19779195, compound → HCID 135588784, compound

Participants

Reaction Steps

In 450 ml of ethyl acetate was dissolved 2.5 g of Compound 1a followed by addition of 0.30 g of 10% palladium-carbon as a catalyst. After purging the atmosphere in the reaction vessel with hydrogen gas, the reaction mixture was stirred at ambient temperature. After 180 ml of hydrogen had been consumed, the reaction mixture was filtered through Celite to remove the catalyst and the filtrate was washed with ethyl acetate and concentrated under reduced pressure. The crude product thus obtained was washed with diethyl ether to give 2.3 g of the desired compound as a colorless solid. The structure and physical properties of the product compound are shown in Table 2.

Provenance & Evidence